Dr. Dinesh Jothimani

Director – Hepatology, Medical Gastroenterology

Dr. Rela Institute & Medical Centre – Chennai.

Qualification: MRCP (UK), FRCP (Glasgow), CCT (Hepatology, UK)

Brief Profile

Dr. Dinesh Jothimani is a Hepatologist and Gastroenterologist and has an experience of 18 years in these fields. He completed MBBS from The Tamil Nadu Dr. M.G.R. Medical University (TNMGRMU) in 2000 and MRCP (UK) from Royal College of Physician, London in 2004.

He is a member of Indian Association for the study of Liver, Indian Society of Gastroenterology, General Medical Council (GMC), UK, European Association of Study of Liver, British association of study of Liver and Fellowship in Royal College of Physicians

Educational Qualifications

• MBBS 2000, Madras Medical College, Chennai, India
• MRCP (UK) 2004, The Royal College of Physicians, UK
• CCT (UK) 2010, General Medical Council, UK

Clinical Expertise

A Liver specialist trained in the UK and Australia. Cares for patients with liver diseases and liver transplantation. Carries out endoscopic procedures including ERCPs and therapeutic endoscopies.

Experience

• Feb 2001 to September 2010 National Health Service, UK
• Oct 2010 – Feb 2011 Consultant Hepatologist, University Hospitals of Coventry & Warwickshire, UK
• April 2011 to July 2012 Consultant Hepatologist, MIOT Hospitals, Chennai, India
• Aug 2012 TO October 2018 Consultant Liver Transplant Physician. Institute of Liver disease and Transplantation. Global Hospitals, Chennai

Honors & Awards

• Times Health Excellence Award 2020 for Service Excellence in Liver & Gastro Care

Research & Publication

Publications:

• Management of post liver transplant recurrent HCV infection with directly acting antiviral drugs (review) D Jothimani, S Govil, M Rela. Accepted. Hepatology International 2016
• Outcome of patients with acute liver failure due to yellow phosphorus poisoning. D Jothimani, J Venkatraman, G Narasimhan, M Rela. Liver Int (submitted)
• Textbook chapter on Liver Regeneration- Elsvier Liver Transplantation September 2015. R Rajalingam, D Jothimani, M Rela
• Role of Mycophenolate mofetil in Autoimmune hepatitis- an observational study. D Jothimani, M Cramp, TJ Cross. JCEH Jun 2014. Volume 4, Issue 3, 221 – 225
• A new era in the management of chronic hepatitis C- A review. D Jothimani, G Chandy, H Conjeevaram. Indian J Gastroenterol. 2013 Mar;32(2):71-9.
• Macrophage secretory products induce an inflammatory phenotype in hepatocytes.  Michelle Melino, Victoria L Gadd, Dinesh Jothimani, Andrew D Clouston, Julie R Jonsson, Elizabeth E Powell. World J Gastroenterol 2012 April 21; 18(15): 1732-1744
• Non-invasive assessment of fibrosis in liver grafts due to hepatitis C recurrence.  TJ Cross, D Jothimani, M Heneghan, P Harrison Clinical Transplantation 2011 May;25(3):345-51
• Treatment of Autoimmune hepatitis- a review of current and evolving therapies. D Jothimani, M Cramp, J Mitchell, TJ Cross. J Gastroenterol Hepatol. 2010 Nov 15. doi: 10.1111/j.1440-1746.2010.06579
• Re: Early use of TIPS in cirrhotic patients with variceal bleeding- Letter   D Jothimani, TJS Cross. N Engl J Med. 2010; 363: 1375-76
• Re: outcome of recurrent hepatitis C virus after liver transplantation in a randomized trial of monotherapy versus triple therapy-Letter. D Jothimani, TJ Cross. Liver Transpl. 2010 May;16(5):68
• Magnetic resonance imaging and spectroscopy accurately estimate the severity of steatosis provided stage of fibrosis is considered. McPherson S, Jonsson J. Jothimani D…Powell E J Hepatol. 2009 Aug;51(2):389-9
• An unusual case of gastric erosions. Jothimani D, Zanetto U, R Owen, P Wilson. Gut. 2009 Dec;58(12):1669, 1708
• Effect of ethnicity on the presentation and management of oesophageal and gastric cancers- A UK perspective. Sadler G, Jothimani D, Zanetto U, M Anderson. Eur J Gastroenterol Hepatol. 2009 Sep;21(9):996-100
• Long term immunosuppression for prevention of non-viral disease recurrence. Neuberger J, Jothimani D. Transplantation Proc May 2005; 37(4):1671-4.
• A case report of hypertension associated with hypokalemia and hyponatremia’ Jothimani D, Morgan N, Snape J. CME Geriatric Medicine, 2005; 7(2): 106-107

Trials/studies/audits:

• NASH in healthy liver donors (2016)
• Prevalence of PNPLA-3 in South Indian population (about to commence)
• Outcome of Acute Liver Failure due to Rat killer poisoning, Global Hospitals, Chennai
• Body mass Index (BMI) and Liver transplantation outcome, Global Hospitals, Chennai
• Markers of significant steatosis in potential liver donors, Global Hospitals, Chennai, India
• Outcome of combined liver kidney transplantation, Global Hospitals, Chennai, India
• TMC-435 study- Protease inhibitor triple therapy in the management of chronic hepatitis C genotype 1 (previous non-responders and relapsers). Principal co-investigator, Derriford Hospital, Plymouth, UK
• Role of Budesonide in Autoimmune hepatitis, Southwest Liver unit, Derriford Hospital, 2010
• ERCP practice Southwest England compared to national standards, Southwest liver unit, Derriford Hospital, 2010
• Efficacy of MMF in refractory Autoimmune hepatitis, Southwest liver unit, Derriford Hospital, 2010
• Effect of weight loss prior to anti-viral response in patients with obesity and chronic hepatitis C infection, Princess Alexandra Hospital, Brisbane, Australia, 2009
• Role of alternatively activated macrophages (Kupffer cells) in obesity related liver injury in patients with chronic hepatitis C infection.  Supervised by A/Prof E Powell
• Factors affecting the response to antiviral treatment in chronic hepatitis   C –Is there a role for CD163? Supervised by A/Prof E Powell
• Effect of weight loss in obese patients prior to commencing    anti- viral treatment for chronic hepatitis C genotype 1. Supervised by A/Prof E Powell
• Role of MRI in the assessment of liver fibrosis. Supervised by A/Prof E Powell
• Role of Portal Tract Lymphoid Tissue (PALT) in Chronic    Hepatitis C Cirrhosis. Supervised by Prof D Adams, University of Birmingham

Posters:

• Predictive factors of NAFLD in healthy liver donors, EASL 2016. Barcelona. D Jothimani, S Govil, M Vij, M Rela
• NASH in potential liver donors, ILTS 2016. Seoul. D Jothimani, S Govil, M Vij, M Rela
• Effect of BMI on post-Liver transplantation short-term outcome. ILTS 2014. London. D Jothimani, S Govil, M Rela
• Predictive Factors of significant steatosis in potential liver donors. ILTS 2014 London. D Jothimani, M Srivatsav, S Reddy, M Rela
• Factors predict significant steatosis in potential liver donors EASL 2014 London. D Jothimani, S Reddy, M Rela
• Combined liver kidney transplantation- ILTS 2013 Sydney
• Variations in the presentation of autoimmune hepatitis. INASL 2013
• Liver stiffness measurement by Transient Elastography in Indian patients D Jothimani, GM Chandy INASL 2012
• Budesonide in Autoimmune Hepatitis, Asia-Pacific Association of Study of Liver disease (APASL), Bangkok, Feb 2011, D Jothimani, T Cross, M Cramp, J Mitchell
• A rare complication of acute hepatitis A infection- case study. Asia-Pacific Association of Study of Liver disease (APASL), Bangkok, Feb 2011. D Jothimani, T Cross, M Cramp, J Mitchell
• MMF in Autoimmune Hepatitis, APASL, Bangkok. Feb 2011, D Jothimani, M Cramp, J Mitchell, T Cross
• Mycophenolate mofetil in patients with Autoimmune hepatitis. BASL   Edinburgh, September 2010 Gut Sep 2010, vol 59, supp 2, A17. D Jothimani, U Warshow, M Cramp, J Mitchell, T Cross
• Practice of ERCP in Southwest England- A survey across 5 cancer networks. AUGIS, September 2010. D Jothimani, D Bailey, J Isaacs, S Jackson
• Sensitivity of Endoscopic Ultrasound in staging Oesophageal cancer. Midlands Gastro Scientific Meeting, June 2008. DK Jothimani, MA Anderson, PG Wilson
• Prevalence of raised ALT in patients with type 2 diabetes mellitus. Midlands Gastro Scientific Meeting, June 2008. DK Jothimani, P De, BT Cooper
• Should we biopsy all gastritis? – A case report. Midlands Gastro Scientific Meeting, June 2008.  DK Jothimani, U Zanetto, RG Owens, PG Wilson
• Bleeding but no blood- A case report. Midlands Gastro Scientific Meeting, November 2007. DK Jothimani, R Murrin, MV Lewis
• Control of Clostridium Associated Diarrhoea (CDAD) in a District Hospital in the UK. UEGW Paris, October 2007. DK Jothimani, S Jones, S Manjunath
• Effect of TPN Monitoring Protocol in a DGH- A Three Year Experience. UEGW Paris, October 2007. DK Jothimani, M Askey, SD Hearing

Oral presentations:

• Acute Liver Failure due to Yellow Phosphorous poisoning. ILTS 2014. London
• Debate- Role of N-Acetyl cysteine in Non-paracetamol acute liver failure. INASL, Jaipur. 2014
• Management of Acute liver failure. INASL, Hyderabad 2013
• Outcome in the management of CLKT- a single centre experience. ISOT Mumbai October 2012
• New molecular pathogenesis and prognostication in HCC. INASL Gawhati 2012
• Drug induced liver injury, UHCW, November 2010
• Practice of ERCP in Southwest England, Southwest Gastroenterology & Hepatology meeting, Newquay, June 2010
• Role of MMF in Autoimmune hepatitis patients intolerant to Azathioprine, Southwest Gastroenterology & Hepatology meeting, Newquay, June 2010
• Effect of weight loss on antiviral treatment response in obese chronic hepatitis C patients- BILG meeting, Brisbane, April 2009
• Control of CDAD in Manor Hospital- A Follow-up data. Midlands Gastro Scientific Meeting, June 2007
• Benign biliary Strictures, Gut Club, February 2006
• Outcome of paracetamol overdose referred to QE. UHB, Birmingham- April 2005

• Languages : English , Hindi, Tamil
• Gender : Male